Blar i forfatter "Arranz, Lorena"

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    • Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche 

      Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-18)
      Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...

    • Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells 

      Vilaplana-Lopera, Nuria; Cuminetti, Vincent; Almaghrabi, Ruba; Papatzikas, Grigorios; Rout, Ashok Kumar; Jeeves, Mark; González, Elena; Alyahyawi, Yara; Cunningham, Alan; Erdem, Ayşegül; Schnütgen, Frank; Raghavan, Manoj; Potluri, Sandeep; Cazier, Jean-Baptiste; Schuringa, Jan Jacob; Reed, Michelle AC; Arranz, Lorena; Günther, Ulrich L; Garcia, Paloma (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether AML cells could establish beneficial metabolic interactions with stromal cells is underexplored. By using a combination of human AML cell lines and AML ...

    • Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation 

      Villatoro, Alicia; Cuminetti, Vincent; Bernal, Aurora; Torroja, Carlos; Cossío, Itziar; Benguría, Alberto; Ferré, Marc; Konieczny, Joanna; Vázquez, Enrique; Rubio, Andrea; Utnes, Peter Andree; You, Xiaona; Fenton, Christopher Graham; Paulssen, Ruth H; Zhang, Jing; Sánchez-Cabo, Fatima; Dopazo, Ana; Vik, Anders; Anderssen, Endre; Hidalgo, Andres; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)
      Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL-1RN and the IL-1β monoclonal antibody canakinumab reduce the expansion of leukemic cells, including CD34+ ...

    • Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities 

      Martínez de Toda, Irene; Rattan, Suresh IS; De la Fuente, Mónica; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-31)
      Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates to low 20S proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on the tissue or cell type and it is ...

    • The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies 

      Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-24)
      The purpose of this review is to present the current knowledge on the clinical use of several forms of cell therapy in hematological malignancies and the preclinical models available for their study. In the context of allogeneic hematopoietic stem cell transplants, mesenchymal stromal cells are pursued to help stem cell engraftment and expansion, and control graft versus host disease. We further ...

    • IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene 

      Thiyagarajan, Dhivya; Pedersen, Hege Lynum; Seredkina, Natalya; Horvei, Kjersti Daae; Arranz, Lorena; Sonneveld, Ramon; Nijenhuis, Tom; van der Vlag, Johan; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-06)
      Recently we described that endonuclease inactive DNase I translocated into the nucleus in response to increased endogenous IL-1β expression. Here, we demonstrate impact and function of translocated DNase I in tubular cells. Effect of cytokines on expression level and nuclear localisation of DNase I and corresponding levels of Fas receptor (FasR) and IL-1β were determined by confocal microscopy, qPCR ...

    • Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications 

      Arranz, Lorena; Arriero Sanchez, Maria Del Mar; Villatoro, Alicia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-03)
      Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target cells. Enhanced IL-1β signaling is a common event in patients of hematological malignancies. Recent body of evidence obtained in preclinical models shows the ...

    • Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia 

      Villatoro, Alicia; Konieczny, Joanna; Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
      Acute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relapse in the long-run by selection of chemoresistant leukemia stem cells (LSC). These may diversify and result in progression to more aggressive forms of AML. <i>In ...

    • Multiple faces of succinate beyond metabolism in blood 

      Grimolizzi, Franco; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-28)
      Succinate is an essential intermediate of the tricarboxylic acid cycle that exerts pleiotropic roles beyond metabolism in both physiological and pathological conditions. Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxiainducible factor-1α activation, post-translational modifications ...

    • Nestin-expressing progenitor cells: function, identity and therapeutic implications 

      Bernal Mera, Aurora; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-14)
      The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role ...

    • Nytt håp for voksne leukemipasienter 

      Arranz, Lorena; Juul, Kjersti (Chronicle; Kronikk, 2023-04-11)
      Norske forskere er i ferd med å utvikle en behandling som øker overlevelsen for voksne leukemipasienter.

    • Updates on old and weary haematopoiesis 

      Konieczny, Joanna; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-29)
      Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific niche or microenvironment where HSCs nest that allows them to retain their unique characteristics and respond rapidly to external stimuli. Ageing is accompanied ...